Résumés
Résumé
L’acétaminophène (APAP) est l’une des molécules les plus consommées par la population. Les infirmier.ères d’urgence doivent donc évaluer quotidiennement des personnes exposées à ce type de molécule, que la dose ingérée soit toxique ou non. Plusieurs conséquences, trop souvent sous-estimées, mais pouvant être fatales, sont associées aux surdoses à l’APAP. L’évaluation initiale dès le triage s’avère donc importante afin d’estimer le risque d’hépatotoxicité, puis de déterminer le besoin de traitement. L’objectif de cet article est donc de guider le personnel infirmier d’urgence lors de l’évaluation des personnes potentiellement intoxiquées à l’APAP et de démystifier la molécule, les types d’exposition, l’analyse des résultats de laboratoire, l’approche thérapeutique appropriée et les critères d’initiation et de cessation du traitement selon le contexte.
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Parties annexes
Remerciements
Les autrices tiennent à remercier Dre Maude St-Onge et Madame Audrée Elliott, pharmacienne, pour leur soutien et la révision de cet article.
Bibliographie
- 1. Saccomano, SJ. (2019). Acute acetaminophen toxicity in adults. Nurse Pract. 2019; 44(11): 42-47. doi: 10.1097/01.NPR.0000586020.15798.c6.
- 2. Nelson LS, Howland MA, Lewin NA, Smith SW, Goldfrank LR, Hoffman RS. Goldfrank’s toxicologic emergencies. 11e éd. New York: McGraw-Hill Education; 2019.
- 3. Centre antipoison du Québec (CAPQ). Base de données ToxiQc. Document inédit.
- 4. St-Onge M. Rapport annuel 2020 : centre antipoison du Québec. 2020. https://www.ciusss-capitalenationale.gouv.qc.ca/sites/default/files/docs/CAPQ/rapport-annuel-2020_francais.pdf
- 5. St-Onge M. Rapport annuel 2021 : centre antipoison du Québec. 2021. https://www.ciusss-capitalenationale.gouv.qc.ca/sites/default/files/docs/CAPQ/rapport-annuel-2020_francais.pdf
- 6. Mazaleuskaya LL, Sangkuhl K, Thorn CF, FitzGerald GA, Altman, RB, & Klein T E. PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015; 25(8): 416. doi: 10.1097/FPC.0000000000000150
- 7. Burns, MJ., Friedman, SL., & Larson, AM. (2023). Acetaminophen (paracetamol) poisoning in adults: Pathophysiology, presentation, and evaluation. UpToDate. 2020. https://www.uptodate.com./contents/acetaminophen-paracetamol-poisoning-in-adults-pathophysiology-presentation-and-evaluation
- 8. Saljoughian, M. Acetaminophen intoxication: a critical-care emergency. US Pharm. 2016; 41(12):38-41
- 9. Ambizas, EM. Acetaminophen toxicity: what pharmacists need to know. US Pharm. 2014; 3: 19.
- 10. Ammar AF, Alkhuzaee M, Alsulami N, Bushah A, Almalki A, Torkistani A, Baeshen M, Afifi M. Mini review study of acetaminophen overdose poisoning and associated factors in cases from poison. Austin Biochem. 2019; 4(1):1021.
- 11. Elliott, A. Hospital referral rates for toddlers exposed to adult-strength, red, sweet-coated acetaminophen tablets. Clinical toxicology. 2021; 59 (11):1141-1141.
- 12. Donroe JH, Tetrault JM. Recognizing and caring for the intoxicated patient in an outpatient clinic. Med Clin North Am. 2017; 101 (3): 573-86. doi: 10.1016/j.mcna.2016.12.012
- 13. Caragea G, Avram O, Pauna A, Costea AC, Tudosie M. Acetaminophen, a therapeutic or an extremely toxic remedy–a review. JMMS. 2022; 9(1): 102-110. https://doi.org/10.22543/7674.91.P102110
- 14. Olson KR, Anderson IB, Benowitz NL, Blanc PD, Clark RF, Kearney TE, Kim-Katz SY, Wu AHB. Poisoning & drug overdose. New York: McGraw-Hill Education; 2012.
- 15. Sandoz Canada inc. Acetylcysteine Solution. 2011. https://pdf.hres.ca/dpd_pm/00015046.PDF
- 16. Centre intégré universitaire de santé et de services sociaux de la Capitale-Nationale (CIUSSS). Guide canadien des antidotes en toxicologie d’urgence. Association canadienne des centres antipoison. 2020. https://www.ciusss-capitalenationale.gouv.qc.ca/antidotes
- 17. Tran K, Horton J. Point-of-care testing and N-Acetylcysteine for acute acetaminophen overdose. Canadian Agency for Drugs and Technologies in Health. 2021; 1(7).
- 18. Wong A, Gunja N, McNulty R, Graudins A. Analysis of an 8-hour acetylcysteine infusion protocol for repeated supratherapeutic ingestion of paracetamol. Clinical Toxicology. 2018; 56(3): 199-203. doi: 10.1080/15563650.2017.1359620
- 19. Yarema M, Chopra P, Sivilotti ML, Johnson D, Nettel-Aguirre A, Bailey B, Victorino C, Gosselin S, Purssell R, Thompson M, Spyker D, Rumack B. Anaphylactoid reactions to intravenous N-Acetylcysteine during treatment for acetaminophen poisoning. J Med Toxicol. 2018; 14(2): 120–127. doi: 10.1007/s13181-018-0653-9.
- 20. Mahmoudi, GA, Astaraki P, Mohtashami AZ, Ahadi M. N-acetylcysteine overdose after acetaminophen poisoning. Int Med Case Rep J. 2015.; 8: 65–69. https://doi.org/10.2147/IMCRJ.S74563
- 21. Cuninghame S, Lotfy K, Cameron P. Massive acetaminophen overdose with metabolic acidosis refractory to N-acetylcysteine, fomepizole, and renal replacement therapy. Toxicol Rep. 2021; 8: 804-807. https://doi.org/10.1016/j.toxrep.2021.03.031
- 22. Mullins ME, Kraut JA. The role of the nephrologist in management of poisoning and intoxication: core Curriculum 2022. Am J Kidney Dis. 2022; 79(6): 877–889. https://doi.org/10.1053/j.ajkd.2021.06.030
- 23. Gosselin S, Juurlink DN., Kielstein JT, Ghannoum M, Lavergne V, Nolin TD, Hoffman RS. Extracorporeal treatment for acetaminophen poisoning: recommendations from the EXTRIP workgroup. Clinical toxicology. 2014;52(8): 856–867. https://doi.org/10.3109/15563650.2014.946994
- 24. Bunchorntavakul C, Reddy KR. Acetaminophen (APAP or N-Acetyl-p-Aminophenol) and acute liver failure. Clin Liver Dis. 2018; 22(2): 325-346. https://doi.org/10.1016/j.cld.2018.01.007
- 25. Tan EX, Wang MX, Pang J, Lee GH. Plasma exchange in patients with acute and acute-on-chronic liver failure: A systematic review. World J Gastroenterol. 2020; 26(2): 219–245. https://doi.org/10.3748/wjg.v26.i2.219
- 26. Larsen FS, Schmidt LE, Bernsmeier C, Rasmussen A, Isoniemi H, Patel VC, Triantafyllou, E, Bernal W, Auzinger G, Shawcross D, Eefsen M, Bjerring PN, Clemmesen, JO, Hockerstedt K, Frederiksen HJ, Hansen BA, Antoniades CG, Wendon J. High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial. J Hepatol. 2016; 64(1): 69–78. https://doi.org/10.1016/j.jhep.2015.08.018
- 27. Furger P, St-Onge M, Bergeron AC. Intoxi-méd: guide thérapeutique. Québec : D&F Éditions; 2013.
- 28. Baxter corporation. Acétaminophène injectable. 2021. https://www.baxter.ca/sites/g/files/ebysai1431/files/2021-08/FR_AC%C3%89TAMINOPH%C3%88NE%20INJECTABLE.pdf
- 29. Bandoli G, Palmsten K, Chambers C. Acetaminophen use in pregnancy: Examining prevalence, timing, and indication of use in a prospective birth cohort. Paediatr Perinat Epidemiol. 2020; 34(3): 237–246. https://doi.org/10.1111/ppe.12595
- 30. Micromedex Solutions. Truven Health Analytics, Inc. Document inédit.
- 31. Jang DH, Weaver MD, Pizon AF. In vitro study of N-acetylcysteine on coagulation factors in plasma samples from healthy subjects. J Med Toxicol. 2013; 9: 49-53. doi: 10.1007/s13181-012-0242-2