Résumés
Résumé
En Amérique du Nord, les troubles des conduites alimentaires, qui incluent par exemple l’anorexie mentale, la boulimie et l’accès hyperphagique, toucheront environ une à cinq personnes sur cent à un moment de leur vie. Les troubles des conduites alimentaires ont de graves conséquences sur la santé physique et psychologique, en plus d’avoir des taux de rémission sous-optimaux. Aussi, l’étiologie des troubles alimentaires est loin d’être élucidée, ce qui nuit au développement d’interventions efficaces. En étudiant les mécanismes neurobiologiques des troubles des conduites alimentaires, par exemple, grâce à des méthodes de neuro-imagerie et d’épigénétique, il sera possible d’obtenir une idée plus claire de leurs origines développementales. Dans le futur, ces nouvelles connaissances pourraient contribuer au développement de stratégies de prévention plus adaptées, d’outils diagnostiques et d’approche de traitement mieux ciblé. Par exemple, le fait d’établir l’association entre la méthylation de l’ADN (l’une des marques épigénétiques) et les changements cérébraux observés dans les troubles des conduites alimentaires pourrait mener à des avancées cliniques importantes. Ainsi, l’objectif de cette revue narrative, réalisée à partir de la base de données Pubmed entre Mars et Octobre 2020, est de résumer l’état des connaissances sur les avancées neurobiologiques récentes dans les troubles des conduites alimentaires, principalement en termes d’épigénétique et de neuro-imagerie.
Mots-clés :
- troubles des conduites alimentaires,
- génétique,
- épigénétique,
- neuro-imagerie,
- marqueurs biologiques,
- développement
Abstract
In North America, eating disorders, which include, for example, Anorexia Nervosa, Bulimia and Binge Eating Disorders, will affect about one to five percent of people at some point in their lives. Eating disorders have great physical and psychological health consequences, and their remission rates are worrisome. The etiology of eating disorders is far from being elucidated, which hinders the development of effective interventions. By studying neurobiological mechanisms of eating disorders, using for example neuroimaging and epigenetic methods, it will be possible to obtain a clearer idea of their developmental origins. In the future, this new knowledge will be helpful to develop adapted prevention strategies, new diagnostic tools and targeted treatment strategies. For example, establishing the association between DNA methylation (an epigenetic modification) and brain changes observed in eating disorders could lead to important clinical advances. Thus, the objective of this narrative review, conducted from the Pubmed database between March and October 2020, is to summarize the state of knowledge on recent neurobiological advances in eating disorders, mainly in terms of epigenetics and neuroimaging.
Keywords:
- eating disorders,
- genetics,
- epigenetics,
- neuroimaging,
- biological markers,
- development
Parties annexes
Bibliographie
- American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5e éd.). American Psychiatric Association. https://doi.org/10.1176/appi.books.9780890425596
- Aparicio-Martinez, P., Perea-Moreno, A.-J., Martinez-Jimenez, M. P., Redel-Macías, M. D., Pagliari, C. et Vaquero-Abellan, M. (2019). Social media, thin-ideal, body dissatisfaction and disordered eating attitudes : an exploratory analysis. International Journal of Environmental Research and Public Health, 16(21). https://doi.org/10.3390/ijerph16214177
- Barona, M., Brown, M., Clark, C., Frangou, S., White, T. et Micali, N. (2019). White matter alterations in anorexia nervosa : Evidence from a voxel-based meta-analysis. Neuroscience and Biobehavioral Reviews, 100, 285-295. https://doi.org/10.1016/j.neubiorev.2019.03.002
- Bianco-Miotto, T., Craig, J. M., Link to external site, this link will open in a new window, Gasser, Y. P., van Dijk, S. J. et Ozanne, S. E. (2017). Epigenetics and DOHaD : From basics to birth and beyond. Journal of Developmental Origins of Health and Disease, 8(5), 513-519. http://dx.doi.org.ezproxy.usherbrooke.ca/10.1017/S2040174417000733
- Boehm, I., Walton, E., Alexander, N., Batury, V.-L., Seidel, M., Geisler, D., King, J. A., Weidner, K., Roessner, V. et Ehrlich, S. (2020). Peripheral serotonin transporter DNA methylation is linked to increased salience network connectivity in females with anorexia nervosa. Journal of Psychiatry and Neuroscience, 45(3), 206-213. https://doi.org/10.1503/jpn.190016
- Booij, L., Casey, K. F., Antunes, J. M., Szyf, M., Joober, R., Israël, M. et Steiger, H. (2015). DNA methylation in individuals with anorexia nervosa and in matched normal-eater controls : A genome-wide study. The International Journal of Eating Disorders, 48(7), 874-882. https://doi.org/10.1002/eat.22374
- Booij, L. et Steiger, H. (2020). Applying epigenetic science to the understanding of eating disorders : A promising paradigm for research and practice. Current Opinion in Psychiatry. https://doi.org/10.1097/YCO.0000000000000632
- Booij, L., Szyf, M., Carballedo, A., Frey, E.-M., Morris, D., Dymov, S., Vaisheva, F., Ly, V., Fahey, C., Meaney, J., Gill, M. et Frodl, T. (2015). DNA methylation of the serotonin transporter gene in peripheral cells and stress-related changes in hippocampal volume : A study in depressed patients and healthy controls. PLOS ONE, 10(3), e0119061. https://doi.org/10.1371/journal.pone.0119061
- Booij, L., Tremblay, R. E., Szyf, M. et Benkelfat, C. (2015). Genetic and early environmental influences on the serotonin system : Consequences for brain development and risk for psychopathology. Journal of Psychiatry et Neuroscience , 40(1), 5-18. https://doi.org/10.1503/jpn.140099
- Brookes, A. J. (1999). The essence of SNPs. Gene, 234(2), 177-186. https://doi.org/10.1016/S0378-1119(99)00219-X
- Brownell, K. D. et Walsh, B. T. (2017). Eating disorders and obesity : A comprehensive handbook (3e éd.). Guilford Press.
- Campbell, I. C., Mill, J., Uher, R. et Schmidt, U. (2011). Eating disorders, gene–environment interactions and epigenetics. Neuroscience & Biobehavioral Reviews, 35(3), 784-793. https://doi.org/10.1016/j.neubiorev.2010.09.012
- Cao-Lei, L., Dancause, K. N., Elgbeili, G., Massart, R., Szyf, M., Liu, A., Laplante, D. P. et King, S. (2015). DNA methylation mediates the impact of exposure to prenatal maternal stress on BMI and central adiposity in children at age 13½ years : Project Ice Storm. Epigenetics, 10(8), 749-761. https://doi.org/10.1080/15592294.2015.1063771
- Casey, B. J., Heller, A. S., Gee, D. G. et Cohen, A. O. (2019). Development of the emotional brain. Neuroscience Letters, 693, 29-34. https://doi.org/10.1016/j.neulet.2017.11.055
- Casey, K. F., Levesque, M. L., Szyf, M., Ismaylova, E., Verner, M.-P., Suderman, M., Vitaro, F., Brendgen, M., Dionne, G., Boivin, M., Tremblay, R. E. et Booij, L. (2017). Birth weight discordance, DNA methylation, and cortical morphology of adolescent monozygotic twins. Human Brain Mapping, 38(4), 2037-2050. https://doi.org/10.1002/hbm.23503
- Chen, V. C.-H., Liu, Y.-C., Chao, S.-H., McIntyre, R. S., Cha, D. S., Lee, Y. et Weng, J.-C. (2018). Brain structural networks and connectomes : The brain–obesity interface and its impact on mental health. Neuropsychiatric Disease and Treatment, 14, 3199-3208. https://doi.org/10.2147/NDT.S180569
- Chesney, E., Goodwin, G. M. et Fazel, S. (2014). Risks of all-cause and suicide mortality in mental disorders : A meta-review. World Psychiatry, 13(2), 153-160. https://doi.org/10.1002/wps.20128
- Chiarella, J., Schumann, L., Pomares, F. B., Frodl, T., Tozzi, L., Nemoda, Z., Yu, P., Szyf, M., Khalid-Khan, S. et Booij, L. (2020). DNA methylation differences in stress-related genes, functional connectivity and gray matter volume in depressed and healthy adolescents. Journal of Affective Disorders, 271, 160-168. https://doi.org/10.1016/j.jad.2020.03.062
- Cliffe, C., Shetty, H., Himmerich, H., Schmidt, U., Stewart, R. et Dutta, R. (2020). Suicide attempts requiring hospitalization in patients with eating disorders : A retrospective cohort study. The International Journal of Eating Disorders, 53(5), 458-465. https://doi.org/10.1002/eat.23240
- Cowdrey, F. A., Filippini, N., Park, R. J., Smith, S. M. et McCabe, C. (2014). Increased resting state functional connectivity in the default mode network in recovered anorexia nervosa. Human Brain Mapping, 35(2), 483-491. https://doi.org/10.1002/hbm.22202
- Duncan, L., Yilmaz, Z., Gaspar, H., Walters, R., Goldstein, J., Anttila, V., Bulik-Sullivan, B., Ripke, S., Eating Disorders Working Group of the Psychiatric Genomics Consortium, Thornton, L., Hinney, A., Daly, M., Sullivan, P. F., Zeggini, E., Breen, G. et Bulik, C. M. (2017). Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa. The American Journal of Psychiatry, 174(9), 850-858. https://doi.org/10.1176/appi.ajp.2017.16121402
- Fairburn, C. G. et Harrison, P. J. (2003). Eating disorders. Lancet, 361(9355), 407-416. https://doi.org/10.1016/S0140-6736(03)12378-1
- Fichter, M. M., Quadflieg, N., Crosby, R. D. et Koch, S. (2017). Long-term outcome of anorexia nervosa : Results from a large clinical longitudinal study. The International Journal of Eating Disorders, 50(9), 1018-1030. https://doi.org/10.1002/eat.22736
- Fouladi, F., Mitchell, J. E., Crosby, R. D., Engel, S. G., Crow, S., Hill, L., Le Grange, D., Powers, P. et Steffen, K. J. (2015). Prevalence of alcohol and other substance use in patients with eating disorders. European Eating Disorders Review: The Journal of the Eating Disorders Association, 23(6), 531-536. https://doi.org/10.1002/erv.2410
- Frank, G. K. W. (2012). Advances in the diagnosis of anorexia nervosa and bulimia nervosa using brain imaging. Expert Opinion on Medical Diagnostics, 6(3), 235-244. https://doi.org/10.1517/17530059.2012.673583
- Frank, G. K. W. (2019). Neuroimaging and eating disorders. Current Opinion in Psychiatry, 32(6), 478-483. https://doi.org/10.1097/YCO.0000000000000544
- Frank, G. K. W., Shott, M. E. et DeGuzman, M. C. (2019). The neurobiology of eating disorders. Child and Adolescent Psychiatric Clinics of North America, 28(4), 629-640. https://doi.org/10.1016/j.chc.2019.05.007
- Frintrop, L., Trinh, S., Liesbrock, J., Leunissen, C., Kempermann, J., Etdöger, S., Kas, M. J., Tolba, R., Heussen, N., Neulen, J., Konrad, K., Päfgen, V., Kiessling, F., Herpertz-Dahlmann, B., Beyer, C. et Seitz, J. (2019). The reduction of astrocytes and brain volume loss in anorexia nervosa-the impact of starvation and refeeding in a rodent model. Translational Psychiatry, 9(1), 159. https://doi.org/10.1038/s41398-019-0493-7
- Frodl, T., Szyf, M., Carballedo, A., Ly, V., Dymov, S., Vaisheva, F., Morris, D., Fahey, C., Meaney, J., Gill, M. et Booij, L. (2015). DNA methylation of the serotonin transporter gene (SLC6A4) is associated with brain function involved in processing emotional stimuli. Journal of Psychiatry et Neuroscience, 40(5), 296-305. https://doi.org/10.1503/jpn.140180
- Gagné-Ouellet, V., Breton, E., Thibeault, K., Fortin, C.-A., Cardenas, A., Guérin, R., Perron, P., Hivert, M.-F. et Bouchard, L. (2020). Mediation Analysis Supports a Causal Relationship between Maternal Hyperglycemia and Placental DNA Methylation Variations at the Leptin Gene Locus and Cord Blood Leptin Levels. International Journal of Molecular Sciences, 21(1), 329. https://doi.org/10.3390/ijms21010329
- Galmiche, M., Déchelotte, P., Lambert, G. et Tavolacci, M. P. (2019). Prevalence of eating disorders over the 2000–2018 period : A systematic literature review. The American Journal of Clinical Nutrition, 109(5), 1402-1413. https://doi.org/10.1093/ajcn/nqy342
- Gaudio, S., Carducci, F., Piervincenzi, C., Olivo, G. et Schiöth, H. B. (2019). Altered thalamo–cortical and occipital–parietal– temporal–frontal white matter connections in patients with anorexia and bulimia nervosa : A systematic review of diffusion tensor imaging studies. Journal of Psychiatry et Neuroscience, 44(5), 324-339. https://doi.org/10.1503/jpn.180121
- Gaudio, S., Wiemerslage, L., Brooks, S. J. et Schiöth, H. B. (2016). A systematic review of resting-state functional-MRI studies in anorexia nervosa : Evidence for functional connectivity impairment in cognitive control and visuospatial and body-signal integration. Neuroscience and Biobehavioral Reviews, 71, 578-589. https://doi.org/10.1016/j.neubiorev.2016.09.032
- Gianni, A. D., De Donatis, D., Valente, S., De Ronchi, D. et Atti, A. R. (2020). Eating disorders : Do PET and SPECT have a role? A systematic review of the literature. Psychiatry Research. Neuroimaging, 300, 111065. https://doi.org/10.1016/j.pscychresns.2020.111065
- Giedd, J. N., Blumenthal, J., Jeffries, N. O., Castellanos, F. X., Liu, H., Zijdenbos, A., Paus, T., Evans, A. C. et Rapoport, J. L. (1999). Brain development during childhood and adolescence : A longitudinal MRI study. Nature Neuroscience, 2(10), 861. https://doi.org/10.1038/13158
- Gluckman, P. D., Hanson, M. A. et Buklijas, T. (2010). A conceptual framework for the developmental origins of health and disease. Journal of Developmental Origins of Health and Disease, 1(1), 6-18. https://doi.org/10.1017/S2040174409990171
- He, J., Cai, Z. et Fan, X. (2017). Prevalence of binge and loss of control eating among children and adolescents with overweight and obesity : An exploratory meta-analysis. The International Journal of Eating Disorders, 50(2), 91-103. https://doi.org/10.1002/eat.22661
- Hedman, A., Breithaupt, L., Hübel, C., Thornton, L. M., Tillander, A., Norring, C., Birgegård, A., Larsson, H., Ludvigsson, J. F., Sävendahl, L., Almqvist, C. et Bulik, C. M. (2019). Bidirectional relationship between eating disorders and autoimmune diseases. Journal of Child Psychology and Psychiatry, 60(7), 803-812. https://doi.org/10.1111/jcpp.12958
- Hochberg, Z., Feil, R., Constancia, M., Fraga, M., Junien, C., Carel, J.-C., Boileau, P., Le Bouc, Y., Deal, C. L., Lillycrop, K., Scharfmann, R., Sheppard, A., Skinner, M., Szyf, M., Waterland, R. A., Waxman, D. J., Whitelaw, E., Ong, K. et Albertsson-Wikland, K. (2011). Child Health, Developmental Plasticity, and Epigenetic Programming. Endocrine Reviews, 32(2), 159-224. https://doi.org/10.1210/er.2009-0039
- Hoffmann, A., Sportelli, V., Ziller, M. et Spengler, D. (2017). Epigenomics of major depressive disorders and schizophrenia : Early life decides. International Journal of Molecular Sciences, 18(8). https://doi.org/10.3390/ijms18081711
- Hussain, A. A., Hübel, C., Hindborg, M., Lindkvist, E., Kastrup, A. M., Yilmaz, Z., Støving, R. K., Bulik, C. M. et Sjögren, J. M. (2019). Increased lipid and lipoprotein concentrations in anorexia nervosa : A systematic review and meta-analysis. International Journal of Eating Disorders, 52(6), 611-629. https://doi.org/10.1002/eat.23051
- Jung, U. J. et Choi, M.-S. (2014). Obesity and its metabolic complications : The role of adipokines and the relationship between obesity, inflammation, insulin resistance, dyslipidemia and nonalcoholic fatty liver disease. International Journal of Molecular Sciences, 15(4), 6184-6223. https://doi.org/10.3390/ijms15046184
- Kaufmann, L.-K., Hänggi, J., Jäncke, L., Baur, V., Piccirelli, M., Kollias, S., Schnyder, U., Martin-Soelch, C. et Milos, G. (2020). Age influences structural brain restoration during weight gain therapy in anorexia nervosa. Translational Psychiatry, 10(1), 1-10. https://doi.org/10.1038/s41398-020-0809-7
- Kazmi, N., Gaunt, T. R., Relton, C. et Micali, N. (2017). Maternal eating disorders affect offspring cord blood DNA methylation : A prospective study. Clinical Epigenetics, 9(1), 120. https://doi.org/10.1186/s13148-017-0418-3
- Kesselmeier, M., Pütter, C., Volckmar, A.-L., Baurecht, H., Grallert, H., Illig, T., Ismail, K., Ollikainen, M., Silén, Y., Keski-Rahkonen, A., Bulik, C. M., Collier, D. A., Zeggini, E., Hebebrand, J., Scherag, A., Hinney, A. et GCAN and WTCCC3. (2018). High-throughput DNA methylation analysis in anorexia nervosa confirms TNXB hypermethylation. The World Journal of Biological Psychiatry, 19(3), 187-199. https://doi.org/10.1080/15622975.2016.1190033
- King, J. A., Frank, G. K. W., Thompson, P. M. et Ehrlich, S. (2018). Structural neuroimaging of anorexia nervosa : Future directions in the quest for mechanisms underlying dynamic alterations. Biological Psychiatry, 83(3), 224-234. https://doi.org/10.1016/j.biopsych.2017.08.011
- Mansur, R. B., Fries, G. R., Subramaniapillai, M., Frangou, S., De Felice, F. G., Rasgon, N., McEwen, B., Brietzke, E. et McIntyre, R. S. (2018). Expression of dopamine signaling genes in the post-mortem brain of individuals with mental illnesses is moderated by body mass index and mediated by insulin signaling genes. Journal of Psychiatric Research, 107, 128-135. https://doi.org/10.1016/j.jpsychires.2018.10.020
- Müller, T. D., Greene, B. H., Bellodi, L., Cavallini, M. C., Cellini, E., Di Bella, D., Ehrlich, S., Erzegovesi, S., Estivill, X., Fernández-Aranda, F., Fichter, M., Fleischhaker, C., Scherag, S., Gratacòs, M., Grallert, H., Herpertz-Dahlmann, B., Herzog, W., Illig, T., Lehmkuhl, U., … Hinney, A. (2012). Fat mass and obesity-associated gene (FTO) in eating disorders : Evidence for association of the rs9939609 obesity risk allele with bulimia nervosa and anorexia nervosa. Obesity Facts, 5(3), 408-419. https://doi.org/10.1159/000340057
- Neyazi, A., Buchholz, V., Burkert, A., Hillemacher, T., de Zwaan, M., Herzog, W., Jahn, K., Giel, K., Herpertz, S., Buchholz, C. A., Dinkel, A., Burgmer, M., Zeeck, A., Bleich, S., Zipfel, S. et Frieling, H. (2019). Association of Leptin Gene DNA methylation with diagnosis and treatment outcome of anorexia nervosa. Frontiers in Psychiatry, 10. https://doi.org/10.3389/fpsyt.2019.00197
- O’Donnell, K. J. et Meaney, M. J. (2017). Fetal origins of mental health : The developmental origins of health and disease hypothesis. American Journal of Psychiatry, 174(4), 319-328. https://doi.org/10.1176/appi.ajp.2016.16020138
- Quinton, N. D., Meechan, D. W., Brown, K., Eastwood, H. et Blakemore, A. I. F. (2004). Single nucleotide polymorphisms in the leptin receptor gene : Studies in anorexia nervosa. Psychiatric Genetics, 14(4), 191–194.
- Riva, G. (2016). Neurobiology of anorexia nervosa : Serotonin dysfunctions link self-starvation with body image disturbances through an impaired body memory. Frontiers in Human Neuroscience, 10. https://doi.org/10.3389/fnhum.2016.00600
- Rivera, H. M., Christiansen, K. J. et Sullivan, E. L. (2015). The role of maternal obesity in the risk of neuropsychiatric disorders. Frontiers in Neuroscience, 9. https://doi.org/10.3389/fnins.2015.00194
- Rui, L. (2013). Brain regulation of energy balance and body weight. Reviews in Endocrine et Metabolic Disorders, 14(4), 387-407. https://doi.org/10.1007/s11154-013-9261-9
- Schaumberg, K., Jangmo, A., Thornton, L. M., Birgegård, A., Almqvist, C., Norring, C., Larsson, H. et Bulik, C. M. (2019). Patterns of diagnostic transition in eating disorders : A longitudinal population study in Sweden. Psychological Medicine, 49(5), 819-827. https://doi.org/10.1017/S0033291718001472
- Seitz, J., Herpertz-Dahlmann, B. et Konrad, K. (2016). Brain morphological changes in adolescent and adult patients with anorexia nervosa. Journal of Neural Transmission (Vienna, Austria: 1996), 123(8), 949-959. https://doi.org/10.1007/s00702-016-1567-9
- Steiger, H. et Booij, L. (2020). Eating disorders, heredity and environmental activation : getting epigenetic concepts into practice. Journal of Clinical Medicine, 9(5), 1332. https://doi.org/10.3390/jcm9051332
- Steiger, H., Booij, L., Kahan, E., McGregor, K., Thaler, L., Fletcher, E., Labbe, A., Joober, R., Israël, M., Szyf, M., Agellon, L. B., Gauvin, L., St-Hilaire, A. et Rossi, E. (2019). A longitudinal, epigenome-wide study of DNA methylation in anorexia nervosa : Results in actively ill, partially weight-restored, long-term remitted and non-eating-disordered women. Journal of Psychiatry et Neuroscience, 44(3), 205-213. https://doi.org/10.1503/jpn.170242
- Steward, T., Menchón, J. M., Jiménez-Murcia, S., Soriano-Mas, C. et Fernández-Aranda, F. (2018). Neural network alterations across eating disorders : A narrative review of fMRI studies. Current Neuropharmacology, 16(8), 1150-1163. https://doi.org/10.2174/1570159X15666171017111532
- Szyf, M. (2015). Epigenetics, a key for unlocking complex CNS disorders? Therapeutic implications. European Neuropsychopharmacology, 25(5), 682-702. https://doi.org/10.1016/j.euroneuro.2014.01.009
- Trace, S. E., Baker, J. H., Peñas-Lledó, E. et Bulik, C. M. (2013). The genetics of eating disorders. Annual Review of Clinical Psychology, 9(1), 589-620. https://doi.org/10.1146/annurev-clinpsy-050212-185546
- van Hoeken, D. et Hoek, H. W. (2020). Review of the burden of eating disorders : Mortality, disability, costs, quality of life, and family burden. Current Opinion in Psychiatry. https://doi.org/10.1097/YCO.0000000000000641
- Vidaña, A. G., Forbush, K. T., Barnhart, E. L., Mildrum Chana, S., Chapa, D. A. N., Richson, B. et Thomeczek, M. L. (2020). Impact of trauma in childhood and adulthood on eating-disorder symptoms. Eating Behaviors, 39, 101426. https://doi.org/10.1016/j.eatbeh.2020.101426
- Volkow, N. D., Wang, G.-J. et Baler, R. D. (2011). Reward, dopamine and the control of food intake : Implications for obesity. Trends in Cognitive Sciences, 15(1), 37-46. https://doi.org/10.1016/j.tics.2010.11.001
- Wang, G. J., Volkow, N. D., Logan, J., Pappas, N. R., Wong, C. T., Zhu, W., Netusil, N. et Fowler, J. S. (2001). Brain dopamine and obesity. Lancet, 357(9253), 354-357. https://doi.org/10.1016/s0140-6736(00)03643-6
- Wang, G.-J., Volkow, N. D., Thanos, P. K. et Fowler, J. S. (2009). Imaging of brain dopamine pathways : Implications for understanding obesity. Journal of Addiction Medicine, 3(1), 8-18. https://doi.org/10.1097/ADM.0b013e31819a86f7
- Watson, H. J., Yilmaz, Z., Thornton, L. M., Hübel, C., Coleman, J. R. I., Gaspar, H. A., Bryois, J., Hinney, A., Leppä, V. M., Mattheisen, M., Medland, S. E., Ripke, S., Yao, S., Giusti-Rodríguez, P., Anorexia Nervosa Genetics Initiative, Hanscombe, K. B., Purves, K. L., Eating Disorders Working Group of the Psychiatric Genomics Consortium, Adan, R. A. H., … Bulik, C. M. (2019). Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa. Nature Genetics, 51(8), 1207-1214. https://doi.org/10.1038/s41588-019-0439-2
- Wheater, E. N. W., Stoye, D. Q., Cox, S. R., Wardlaw, J. M., Drake, A. J., Bastin, M. E. et Boardman, J. P. (2020). DNA methylation and brain structure and function across the life course : A systematic review. Neuroscience and Biobehavioral Reviews, 113, 133-156. https://doi.org/10.1016/j.neubiorev.2020.03.007
- Winston, A. P. (2020). Eating Disorders and Diabetes. Current Diabetes Reports, 20(8), 32. https://doi.org/10.1007/s11892-020-01320-0
- Yilmaz, Z., Hardaway, J. A. et Bulik, C. M. (2015). Genetics and Epigenetics of Eating Disorders. Advances in Genomics and Genetics, 5, 131-150. https://doi.org/10.2147/AGG.S55776
- Zerwas, S., Larsen, J. T., Petersen, L., Thornton, L. M., Quaranta, M., Koch, S. V., Pisetsky, D., Mortensen, P. B. et Bulik, C. M. (2017). Eating disorders, autoimmune, and autoinflammatory disease. Pediatrics, 140(6). https://doi.org/10.1542/peds.2016-2089
- Zhang, S., Wang, W., Su, X., Kemp, G. J., Yang, X., Su, J., Tan, Q., Zhao, Y., Sun, H., Yue, Q. et Gong, Q. (2018). Psychoradiological investigations of gray matter alterations in patients with anorexia nervosa. Translational Psychiatry, 8(1), 1-11. https://doi.org/10.1038/s41398-018-0323-3