Résumés
Résumé
Des travaux récents réalisés in vitro montrent que l’appauvrissement du milieu de culture en oxygène (hypoxie) active la réplication du parvovirus humain B19, des virus du sarcome de Kaposi et de l’immunodéficience humaine, ainsi que l’expression de protéines virales oncogènes. Les mécanismes de cette régulation impliquent le plus souvent le facteur cellulaire majeur de réponse à l’hypoxie, HIF-1 (hypoxia inducible factor-1). Le dérèglement de ce facteur de transcription participe également au pouvoir oncogène de certains de ces virus.
Summary
Recent studies show that low oxygen tension levels in cell culture up-regulate the replication of human B19 parvovirus, Kaposi’s sarcoma, and human immunodeficiency viruses as well as the expression of viral oncogenic proteins. The mechanisms of this regulation proceed with the major hypoxia-related factor, HIF-1 (hypoxia inducible factor-1). HIF-1 misregulation is implicated in the oncogenesis potential of some of these viruses.
Parties annexes
Références
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