Résumés
Résumé
La méthylation de l’ADN joue un rôle central au cours du développement et de la cancérogenèse et est essentielle pour le verrouillage de l’expression génique. La récente caractérisation des méthyltransférases de l’ADN (Dnmt) et de leurs partenaires protéiques a permis de lever le voile sur plusieurs mécanismes par lesquels la méthylation réprime la transcription et contribue à la cancérogenèse. Ces nouvelles découvertes ont d’importantes implications aussi bien pour la compréhension de la régulation génique que pour celles des mécanismes de l’oncogenèse. En outre, étant donné le caractère réversible de la méthylation, ces études ouvrent de nouvelles perspectives vers une thérapie épigénétique du cancer.
Summary
DNA methylation plays a pivotal role during development and carcinogenesis and is central to gene silencing. The recent characterization of the DNA methyltransferases - Dnmt- and their protein partners have helped to understand the molecular basis underlying methylation-mediated gene silencing and its involvment in cancer. These discoveries have important implications to the comprehension of transcriptional regulation but also to understand the molecular basis underlying tumorigenesis. Moreover, these studies open new ways towards an epigenetic therapy of cancer.
Parties annexes
Références
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