Résumés
Résumé
Par-delà le travail exceptionnel de Sydney Brenner, John Sulston et Bob Horvitz, le prix Nobel de Médecine et de Physiologie 2002 vient couronner une aventure scientifique unique construite autour d’un organisme modèle, le nématode Caenorhabditis elegans. Ce prix Nobel est un éloge de la vision, de la persévérance, et de l’esprit de communauté, sentiment très fort et très vivant parmi les aficionados de C. elegans.
Parties annexes
Références
- 1. Brenner S. The genetics of Caenorhabditis elegans.Genetics 1974; 77: 71-94.
- 2. Sulston JE, Horvitz HR. Post-embryonic cell lineages of the nematode Caenorhabditis elegans. Dev Biol 1977; 56: 110-56.
- 3. Sulston JE, Schierenberg E, White JG, Thomson JN.The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev Biol 1983; 100: 64-119.
- 4. Hedgecock EM, Sulston JE, Thomson JN. Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegans.Science 1983; 220: 1277-9.
- 5. The C. elegans Sequencing Consortium. Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 1998; 282: 2012-8.
- 6. Ellis HM, Horvitz HR. Genetic control of programmed cell death in the nematode C. elegans. Cell 1986; 44: 817-29.
- 7. Ellis RE, Horvitz HR. Two C. elegans genes control the programmed deaths of specific cells in the pharynx. Development 1991; 112: 591-603.
- 8. Hengartner MO, Horvitz HR. C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2. Cell 1994; 76: 665-76.
- 9. Conradt B, Horvitz HR. The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator gene. Cell 1999; 98: 317-27.
- 10. Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell 1993; 75: 641-52.
- 11. Wu YC, Horvitz HR. C. elegans phagocytosis and cell-migration protein CED-5 is similar to human DOCK180. Nature 1998; 392: 501-4.