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Appendices
Remerciements
Je remercie Geneviève Mailhot, Dt.P., Ph. D., du Centre de recherche du CHU Sainte-Justine pour la supervision du stage qui a mené à la rédaction de cet article.
Bibliographie
- 1. Chen P-L, Lee N-Y, Cia C-T, Ko W-C, Hsueh P-R. A Review of Treatment of Coronavirus Disease 2019 (COVID-19): Therapeutic Repurposing and Unmet Clinical Needs. Front Pharmacol. 2020 ;11:584956.
- 2. World Health Organization. Therapeutics and COVID-19: living guideline [En ligne]. 2021 [cité le 9 avril 2021 ]. Disponible : https://www.who.int/publications/i/item/WHO-2019-nCoV-therapeutics-2021.1.
- 3. Martineau AR, Forouhi NG. Vitamin D for COVID-19: a case to answer ? The Lancet Diabetes & Endocrinology. 2020 ;8(9):735-6.
- 4. Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014 ;21(3):319-29.
- 5. Marino R, Misra M. Extra-Skeletal Effects of Vitamin D. Nutrients. 2019 ;11(7):1460.
- 6. Wacker M, Holick MF. Vitamin D – effects on skeletal and extraskeletal health and the need for supplementation. Nutrients. 2013 ;5(1):111-48.
- 7. Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Reviews in Endocrine and Metabolic Disorders. 2017 ;18(2):153-65.
- 8. Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, et coll. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. The Journal of clinical endocrinology and metabolism. 2011 ;96(1):53-8.
- 9. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. The Journal of Clinical Endocrinology & Metabolism. 2011 ;96(7):1911-30.
- 10. Gilbert CR, Arum SM, Smith CM. Vitamin D deficiency and chronic lung disease. Can Respir J. 2009 ;16(3):75-80.
- 11. Dancer RC, Parekh D, Lax S, D’Souza V, Zheng S, Bassford CR, et al. Vitamin D deficiency contributes directly to the acute respiratory distress syndrome (ARDS). Thorax. 2015 ;70(7):617-24.
- 12. Jolliffe DA, Greenberg L, Hooper RL, Griffiths CJ, Camargo CA, Kerley CP, et al. Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data. Lancet Respir Med. 2017 ;5(11):881-90.
- 13. Zhu M, Wang T, Wang C, Ji Y. The association between vitamin D and COPD risk, severity, and exacerbation: an updated systematic review and meta-analysis. International journal of chronic obstructive pulmonary disease. 2016 ;11:2597-607.
- 14. Martineau AR, Jolliffe DA, Hooper RL, Greenberg L, Aloia JF, Bergman P, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ (Clinical research ed). 2017 ;356:i6583.
- 15. Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review. JAMA. 2020 ;324(8):782-93.
- 16. Zambrano LD, Ellington S, Strid P, Galang RR, Oduyebo T, Tong VT, et coll. Update: Characteristics of Symptomatic Women of Reproductive Age with Laboratory-Confirmed SARS-CoV-2 Infection by Pregnancy Status - United States, January 22-October 3, 2020. MMWR Morb Mortal Wkly Rep. 2020 ;69(44):1641-7.
- 17. Malek Mahdavi A. A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19. Reviews in medical virology. 2020 ;30(5):e2119.
- 18. Greiller CL, Martineau AR. Modulation of the immune response to respiratory viruses by vitamin D. Nutrients. 2015 ;7(6):4240-70.
- 19. Hansdottir S, Monick MM. Vitamin D effects on lung immunity and respiratory diseases. Vitam Horm. 2011 ;86:217-37.
- 20. Bleizgys A. Vitamin D and COVID-19: It is time to act. International Journal of Clinical Practice. 2020 ;75:e13748.
- 21. Chen H, Lu R, Zhang Y-G, Sun J. Vitamin D Receptor Deletion Leads to the Destruction of Tight and Adherens Junctions in Lungs. Tissue Barriers. 2018 ;6(4):1-13.
- 22. Rehan VK, Torday JS, Peleg S, Gennaro L, Vouros P, Padbury J, et al. 1Alpha,25-dihydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxy vitamin D3: production and biological activity studies in pulmonary alveolar type II cells. Molecular genetics and metabolism. 2002 ;76(1):46-56.
- 23. Merzon E, Tworowski D, Gorohovski A, Vinker S, Golan Cohen A, Green I, et al. Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study. FEBS J. 2020 ;287(17):3693-702.
- 24. Mardani R, Alamdary A, Mousavi Nasab SD, Gholami R, Ahmadi N, Gholami A. Association of vitamin D with the modulation of the disease severity in COVID-19. Virus Research. 2020 ;289:198148.
- 25. Baktash V, Hosack T, Patel N, Shah S, Kandiah P, Van den Abbeele K, et al. Vitamin D status and outcomes for hospitalised older patients with COVID-19. Postgraduate medical journal. 2020 ;138712.
- 26. Liu N, Sun J, Wang X, Zhang T, Zhao M, Li H. Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis. International Journal of Infectious Diseases. 2021 ;104:58-64.
- 27. Hernández JL, Nan D, Fernandez-Ayala M, García-Unzueta M, Hernández-Hernández MA, López-Hoyos M, et al. Vitamin D Status in Hospitalized Patients with SARS-CoV-2 Infection. The Journal of clinical endocrinology and metabolism. 2021 ;106(3):e1343-e53.
- 28. Im JH, Je YS, Baek J, Chung M-H, Kwon HY, Lee J-S. Nutritional status of patients with COVID-19. Int J Infect Dis. 2020 ;100:390-3.
- 29. Ye K, Tang F, Liao X, Shaw BA, Deng M, Huang G, et al. Does Serum Vitamin D Level Affect COVID-19 Infection and Its Severity ?-A Case-Control Study. Journal of the American College of Nutrition [En ligne]. 13 oct 2020 [cité le 20 mars 2021]:[environ 8 p.] Disponible : https://www.tandfonline.com/doi/full/10.1080/07315724.2020.1826005
- 30. Abdollahi A, Kamali Sarvestani H, Rafat Z, Ghaderkhani S, Mahmoudi-Aliabadi M, Jafarzadeh B, et al. The association between the level of serum 25(OH) vitamin D, obesity, and underlying diseases with the risk of developing COVID-19 infection: A case–control study of hospitalized patients in Tehran, Iran. Journal of medical virology. 2021 ;93(4):2359-64.
- 31. Sulli A, Gotelli E, Casabella A, Paolino S, Pizzorni C, Alessandri E, et al. Vitamin D and Lung Outcomes in Elderly COVID-19 Patients. Nutrients. 2021 ;13(3):717.
- 32. Luo X, Liao Q, Shen Y, Li H, Cheng L. Vitamin D Deficiency Is Inversely Associated with COVID-19 Incidence and Disease Severity in Chinese People. The Journal of nutrition. 2021 ;151(1):98-103.
- 33. Pereira M, Dantas Damascena A, Galvão Azevedo LM, de Almeida Oliveira T, da Mota Santana J. Vitamin D deficiency aggravates COVID-19: systematic review and meta-analysis. Critical reviews in food science and nutrition [En ligne]. 4 nov 2020 [cité le 20 mars 2021]:[environ 9 p.] Disponible : https://www.tandfonline.com/doi/full/10.1080/10408398.2020.1841090.
- 34. D’Avolio A, Avataneo V, Manca A, Cusato J, De Nicolò A, Lucchini R, et coll. 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2. Nutrients. 2020 ;12(5):1359.
- 35. Hastie CE, Mackay DF, Ho F, Celis-Morales CA, Katikireddi SV, Niedzwiedz CL, et al. Vitamin D concentrations and COVID-19 infection in UK Biobank. Diabetes Metab Syndr. 2020 ;14(4):561-5.
- 36. Kaufman HW, Niles JK, Kroll MH, Bi C, Holick MF. SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels. PloS one. 2020 ;15(9):e0239252.
- 37. Meltzer DO, Best TJ, Zhang H, Vokes T, Arora V, Solway J. Association of Vitamin D Status and Other Clinical Characteristics With COVID-19 Test Results. JAMA Network Open. 2020 ;3(9):e2019722.
- 38. Katz J, Yue S, Xue W. Increased risk for COVID-19 in patients with vitamin D deficiency. Nutrition. 2020 ;84:111106.
- 39. Amin HA, Drenos F. No evidence that vitamin D is able to prevent or affect the severity of COVID-19 in individuals with European ancestry: a Mendelian randomisation study of open data. BMJ Nutr Prev Health. 2021:bmjnph-2020-000151.
- 40. Orchard L, Baldry M, Nasim-Mohi M, Monck C, Saeed K, Grocott MPW, Ahilanandan D. Vitamin-D levels and intensive care unit outcomes of a cohort of critically ill COVID-19 patients. Clin Chem Lab Med. 2021 Jan 19 ;59(6):1155-1163.
- 41. Radujkovic A, Hippchen T, Tiwari-Heckler S, Dreher S, Boxberger M, Merle U. Vitamin D Deficiency and Outcome of COVID-19 Patients. Nutrients. 2020 ;12(9).
- 42. Gavioli EM, Miyashita H, Hassaneen O, Siau E. An Evaluation of Serum 25-Hydroxy Vitamin D Levels in Patients with COVID-19 in New York City. Journal of the American College of Nutrition [En ligne]. 19 fév 2021[cité le 20 mars 2021]:[environ 6 p.]. Disponible : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7898298/
- 43. Angelidi AM, Belanger MJ, Lorinsky MK, Karamanis D, Chamorro-Pareja N, Ognibene J, et al. Vitamin D Status Is Associated With In-Hospital Mortality and Mechanical Ventilation: A Cohort of COVID-19 Hospitalized Patients. Mayo Clinic Proceedings. 2021 ;96(4):875-86.
- 44. Jain A, Chaurasia R, Sengar NS, Singh M, Mahor S, Narain S. Analysis of vitamin D level among asymptomatic and critically ill COVID-19 patients and its correlation with inflammatory markers. Scientific Reports. 2020 ;10(1):20191.
- 45. Abrishami A, Dalili N, Mohammadi Torbati P, Asgari R, Arab-Ahmadi M, Behnam B, Sanei-Taheri M. Possible association of vitamin D status with lung involvement and outcome in patients with COVID-19: a retrospective study. Eur J Nutr. 2021 Jun ;60(4):2249-2257.
- 46. Ricci A, Pagliuca A, D’Ascanio M, Innammorato M, De Vitis C, Mancini R, et al. Circulating Vitamin D levels status and clinical prognostic indices in COVID-19 patients. Respiratory research. 2021 ;22(1):76.
- 47. Demir M, Demir F, Aygun H. Vitamin D deficiency is associated with COVID-19 positivity and severity of the disease. Journal of medical virology. 2021 ;93(5):2992-9.
- 48. Basaran N, Adas M, Gokden Y, Turgut N, Yildirmak T, Guntas G. The relationship between vitamin D and the severity of COVID-19. Bratislavske lekarske listy. 2021 ;122(3):200-5.
- 49. Munshi R, Hussein MH, Toraih EA, Elshazli RM, Jardak C, Sultana N, et al. Vitamin D insufficiency as a potential culprit in critical COVID-19 patients. Journal of medical virology. 2021 ;93(2):733-40.
- 50. Lohia P, Nguyen P, Patel N, Kapur S. Exploring the link between vitamin D and clinical outcomes in COVID-19. American journal of physiology Endocrinology and metabolism. 2021 ;320(3):E520-e6.
- 51. Cereda E, Bogliolo L, Klersy C, Lobascio F, Masi S, Crotti S, et al. Vitamin D 25OH deficiency in COVID-19 patients admitted to a tertiary referral hospital. Clinical nutrition (Edinburgh, Scotland). 2020 ;40(4):2469-72.
- 52. Pizzini A, Aichner M, Sahanic S, Böhm A, Egger A, Hoermann G, et al. Impact of Vitamin D Deficiency on COVID-19-A Prospective Analysis from the CovILD Registry. Nutrients. 2020 ;12(9).
- 53. Szeto B, Zucker JE, LaSota ED, Rubin MR, Walker MD, Yin MT, Cohen A. Vitamin D Status and COVID-19. Clinical Outcomes in Hospitalized Patients. Endocr Res. 2021 Feb-May ;46(2):66-73.
- 54. Karahan S, Katkat F. Impact of Serum 25(OH) Vitamin D Level on Mortality in Patients with COVID-19 in Turkey. The journal of nutrition, health & aging. 2021 ;25(2):189-96.
- 55. Vassiliou AG, Jahaj E, Pratikaki M, Orfanos SE, Dimopoulou I, Kotanidou A. Low 25-Hydroxyvitamin D Levels on Admission to the Intensive Care Unit May Predispose COVID-19 Pneumonia Patients to a Higher 28-Day Mortality Risk: A Pilot Study on a Greek ICU Cohort. Nutrients. 2020 ;12(12):3773.
- 56. Infante M, Buoso A, Pieri M, Lupisella S, Nuccetelli M, Bernardini S, et coll. Low Vitamin D Status at Admission as a Risk Factor for Poor Survival in Hospitalized Patients With COVID-19: An Italian Retrospective Study. Journal of the American College of Nutrition [En ligne]. 18 fév 2021 [cité le 20 mars 2021]:[environ 16 p.]. Disponible : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7899172/
- 57. De Smet D, De Smet K, Herroelen P, Gryspeerdt S, Martens GA. Serum 25(OH)D Level on Hospital Admission Associated With COVID-19 Stage and Mortality. American journal of clinical pathology. 2021 ;155(3):381-8.
- 58. Carpagnano GE, Di Lecce V, Quaranta VN, Zito A, Buonamico E, Capozza E, et al. Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19. J Endocrinol Invest. 2021 ;44(4):765-71.
- 59. Bennouar S, Cherif AB, Kessira A, Bennouar D-E, Abdi S. Vitamin D Deficiency and Low Serum Calcium as Predictors of Poor Prognosis in Patients with Severe COVID-19. Journal of the American College of Nutrition. 2021 ;40(2):104-10.
- 60. Hastie CE, Pell JP, Sattar N. Vitamin D and COVID-19 infection and mortality in UK Biobank. Eur J Nutr. 2021 ;60(1):545-8.
- 61. Arvinte C, Singh M, Marik PE. Serum Levels of Vitamin C and Vitamin D in a Cohort of Critically Ill COVID-19 Patients of a North American Community Hospital Intensive Care Unit in May 2020: A Pilot Study. Med Drug Discov. 2020 ;8:100064.
- 62. Silva MC, Furlanetto TW. Does serum 25-hydroxyvitamin D decrease during acute-phase response ? A systematic review. Nutrition Research. 2015 ;35(2):91-6.
- 63. NIH. Clinicaltrials.gov [En ligne]. 2020 [cité le 20 mars 2021 ]. Disponible : https://clinicaltrials.gov/ct2/results?cond=SARS-CoV-2&term=vitamin+D&cntry=&state=&city=&dist=&Search=Search&type=Intr
- 64. Entrenas Castillo M, Entrenas Costa LM, Vaquero Barrios JM, Alcalá Díaz JF, López Miranda J, Bouillon R, et al. «Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study». J Steroid Biochem Mol Biol. 2020 ;203:105751.
- 65. Rastogi A, Bhansali A, Khare N, Suri V, Yaddanapudi N, Sachdeva N, et al. Short term, high-dose vitamin D supplementation for COVID-19 disease: a randomised, placebo-controlled, study (SHADE study). Postgraduate Medical Journal. 2020:postgradmedj-2020-139065.
- 66. CDC. Interim guidance on duration of isolation and precautions for adults with COVID-19 [En ligne]. 2021 [cité le 20 mars 2021]. Disponible : https://www.cdc.gov/coronavirus/2019-ncov/hcp/duration-isolation.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fcoronavirus%2F2019-ncov%2Fcommunity%2Fstrategy-discontinue-isolation.html#references
- 67. Murai IH, Fernandes AL, Sales LP, Pinto AJ, Goessler KF, Duran CSC, et al. Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial. JAMA. 2021 ;325(11):1053-60.
- 68. Annweiler C, Hanotte B, Grandin de l’Eprevier C, Sabatier J-M, Lafaie L, Célarier T. Vitamin D and survival in COVID-19 patients : A quasi-experimental study. J Steroid Biochem Mol Biol. 2020 ;204:105771.
- 69. Ling SF, Broad E, Murphy R, Pappachan JM, Pardesi-Newton S, Kong MF, et al. High-Dose Cholecalciferol Booster Therapy is Associated with a Reduced Risk of Mortality in Patients with COVID-19: A Cross-Sectional Multi-Centre Observational Study. Nutrients. 2020 ;12(12):3799.
- 70. Tan CW, Ho LP, Kalimuddin S, Cherng BPZ, Teh YE, Thien SY, et al. Cohort study to evaluate the effect of vitamin D, magnesium, and vitamin B12 in combination on progression to severe outcomes in older patients with coronavirus (COVID-19). Nutrition. 2020 ;79-80:111017.
- 71. Annweiler G, Corvaisier M, Gautier J, Dubée V, Legrand E, Sacco G, et coll. Vitamin D Supplementation Associated to Better Survival in Hospitalized Frail Elderly COVID-19 Patients: The GERIA-COVID Quasi-Experimental Study. Nutrients. 2020 ;12(11):3377.
- 72. Giannini S, Passeri G, Tripepi G, Sella S, Fusaro M, Arcidiacono G, et al. Effectiveness of In-Hospital Cholecalciferol Use on Clinical Outcomes in Comorbid COVID-19 Patients: A Hypothesis-Generating Study. Nutrients. 2021 ;13(1):219.
- 73. Cereda E, Bogliolo L, Lobascio F, Barichella M, Zecchinelli AL, Pezzoli G, et al. Vitamin D supplementation and outcomes in coronavirus disease 2019 (COVID-19) patients from the outbreak area of Lombardy, Italy. Nutrition. 2021 ;82:111055.
- 74. Shah K, Saxena D, Mavalankar D. Vitamin D supplementation, COVID-19 and disease severity: a meta-analysis. QJM: An International Journal of Medicine. 2021 ;hcab009.
- 75. Grant WB, Lahore H, McDonnell SL, Baggerly CA, French CB, Aliano JL, et al. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients. 2020 ;12(4):988.
- 76. Chakhtoura M, Napoli N, El Hajj Fuleihan G. Commentary: Myths and facts on vitamin D amidst the COVID-19 pandemic. Metabolism. 2020 ;109:154276.
- 77. Ali N. Role of vitamin D in preventing of COVID-19 infection, progression and severity. Journal of Infection and Public Health. 2020 ;13(10):1373-80.
- 78. Bergman P. The link between vitamin D and COVID-19: distinguishing facts from fiction. Journal of internal medicine. 2021 ;289(1):131-3.
- 79. Ferder L, Martín Giménez VM, Inserra F, Tajer C, Antonietti L, Mariani J, et coll. Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemic. American journal of physiology Lung cellular and molecular physiology. 2020 ;319(6):L941-l8.
- 80. Sahebnasagh A, Saghafi F, Avan R, Khoshi A, Khataminia M, Safdari M, et al. The prophylaxis and treatment potential of supplements for COVID-19. European Journal of Pharmacology. 2020 ;887:173530.
- 81. Chandran M, Chan Maung A, Mithal A, Parameswaran R. Vitamin D in COVID - 19: Dousing the fire or averting the storm ? –A perspective from the Asia-Pacific. Osteoporosis and Sarcopenia. 2020 ;6(3):97-105.
- 82. Ebadi M, Montano-Loza AJ. Perspective: improving vitamin D status in the management of COVID-19. European journal of clinical nutrition. 2020 ;74(6):856-9.
- 83. Santé Canada. La vitamine D et le calcium : Révision des Apports nutritionnels de référence [En ligne]. 2020 [cité le 9 avril 2021]. Disponible : https://www.canada.ca/fr/sante-canada/services/aliments-nutrition/saine-alimentation/vitamines-mineraux/vitamine-calcium-revision-apports-nutritionnels-reference.html
- 84. Alberta Health Services. COVID-19 Scientific Advisory Group Rapid Evidence Brief. Vitamin D in the Treatment and Prevention of COVID-19 [En ligne]. 2020 [cité le 9 avril 2021]. Disponible : https://www.albertahealthservices.ca/assets/info/ppih/if-ppih-covid-19-sag-rapid-review-vitamin-d-treatment-and-prevention-covid-19.pdf
- 85. Santé publique Ontario. Association of Vitamin D Status with COVID-19 Incidence and Outcomes, and Health Equity Considerations [En ligne]. 2021 [cité le 9 avril 2021]. Disponible : https://www.publichealthontario.ca/-/media/documents/ncov/he/2021/02/covid-19-rapid-review-vitamin-d.pdf?la=en
- 86. Institut national d’excellence en santé et en services sociaux (INESSS). COVID-19 et Vitamine D [En ligne]. 2021 [cité le 9 avril 2021]. Disponible : https://www.inesss.qc.ca/fileadmin/doc/INESSS/COVID-19/COVID-19_INESSS_Vitamine_D.pdf
- 87. Ostéoporose Canada. Calcium et vitamine D [En ligne]. 2020 [cité le 9 avril 2021]. Disponible : https://osteoporosecanada.ca/sante-des-os-et-osteoporose/calcium-et-vitamine-d/
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